Comprehensive In Vitro and In Vivo Validation of CAR-T Cell Therapies
Evaluate and validate your CAR-T cell therapies with our comprehensive platform that combines in vitro co-culture assays and in vivo studies. Our in vitro assays rigorously assess the efficacy of CAR-T constructs against target cells in controlled environments. Following in vitro validation, we offer precise in vivo assays, including CAR-T cell injections and efficacy studies […]
Lymphoma Data Hub (LDH)
The LDH is a collaborative research platform in digital health, specialized in data management and technological support for biomedical research. Our services include secure cloud hosting for health data, end-to-end data management from raw data deposit to ready-to-use datasets, and the deployment of advanced tools to enable research projects in artificial intelligence and bioinformatics.
CeVi Collection
The CeVi collection is a unique collection of cryopreserved viable human cells from lymphomas and reactive lymphoid tissues. It is structured around a national network of Biological Resource Centres (BRCs) and is dedicated to the use of CALYM consortium members and their partners, with the aim of accelerating lymphoma research.
Nutrient Metabolism analysis and characterization
Our expertise include profiling intracellular metabolites by LC-MS, tracing metabolites into fatty acids, and performing lipidomic analysis for a comprehensive understanding of lipid metabolism. We also offer extracellular flux analysis to assess nutrient utilization and evaluate mitochondrial complexes, shedding light on cellular energy dynamics. Tailored for a range of experimental models, including cell lines, patient-derived […]
Cytokine Profiling
Our expertise include multiplex cytokine assays, ELISA, and intracellular cytokine staining, offering precise quantification and characterization of cytokines across a wide array of samples. We also provide flow cytometry-based analysis to evaluate cytokine production at the single-cell level. These methods are adaptable to various experimental models, including cell lines, patient-derived samples, and in vivo studies, […]
Optimized CAR-T Cell Generation and Transduction
Advance your immunotherapy research with our comprehensive platform for T-cell activation and CAR-T cell generation. We specialize in optimizing T-cell transduction and generating CAR-T cells using classic CAR constructs like CD19-BBz and CD19-CD28. Our expertise ensures efficient and reliable production of CAR-T cells, tailored to meet your research needs.
Labeled Nutrient-Transporter Ligand Production
Enhance your research with our specialized production of labeled nutrient-transporter ligands, developed in partnership with Metafora Biosystems. These labeled ligands enable precise detection of transporter expression, activity, and efficacy, offering new insights into nutrient transport mechanisms.
Mouse Cell line Derived Xenographt (Mouse-CDX)
Explore our Mouse CDX models (parental and CRISPR-Cas9 engineered) to investigate lymphoma and Multiple Myeloma biology, identify novel drug targets and testing for drug efficacy and toxicity.
Multiple Myeloma cell lines
Explore our panel of human myeloma cell lines, including parental and CRISPR- or shRNA-engineered models, extensively characterized at molecular and phenotypic levels. Our collection also includes drug-resistant lines, supporting research on multiple myeloma biology, therapeutic targets, and resistance mechanisms
Precision Gene Modulation with Antisense Oligonucleotides (ASOs)
Our advanced Antisense Oligonucleotides (ASOs) design technologys offer a versatile approach for precisely manipulating gene expression, including the potent capability of exon skipping to modulate protein production, such as Ig genes or BCR, by targeting donor splice sites. This method is compatible with both cell lines and primary cells, offering flexibility and applicability across various […]