Multicellulare Agregates of Lymphoma Cells (MALC)
Explore complex tumor biology with our Multicellular Aggregates of Lymphoma Cells (MALC) model. It mimics the 3D structure and microenvironment of lymphoma, providing a robust system for studying cell-cell interactions, tumor progression, and therapeutic responses. The MALC model enables more physiologically relevant insights compared to traditional 2D cultures, supporting the development of targeted lymphoma therapies.
Lymphoma Data Hub (LDH)
The LDH is a collaborative research platform in digital health, specialized in data management and technological support for biomedical research. Our services include secure cloud hosting for health data, end-to-end data management from raw data deposit to ready-to-use datasets, and the deployment of advanced tools to enable research projects in artificial intelligence and bioinformatics.
3D Co-Culture of Lymphoma Cells with Gamma Delta T Cells
Explore our 3D co-culture system combining lymphoma cell lines and gamma delta T cells from healthy donors. This advanced model recreates the tumor microenvironment, allowing detailed study of immune-tumor interactions, gamma delta T cell cytotoxicity, and potential therapeutic mechanisms.
CeVi Collection
The CeVi collection is a unique collection of cryopreserved viable human cells from lymphomas and reactive lymphoid tissues. It is structured around a national network of Biological Resource Centres (BRCs) and is dedicated to the use of CALYM consortium members and their partners, with the aim of accelerating lymphoma research.
Patient-Derived Lymphoma Spheroids (PDLS)
Explore our Patient-Derived Lymphoma Spheroids (PDLS), a cutting-edge 3D organoid model developed directly from patient samples. PDLS offer an accurate representation of tumor architecture and microenvironment, enabling the study of tumor behavior, drug response, and personalized treatment strategies.
Nutrient Metabolism analysis and characterization
Our expertise include profiling intracellular metabolites by LC-MS, tracing metabolites into fatty acids, and performing lipidomic analysis for a comprehensive understanding of lipid metabolism. We also offer extracellular flux analysis to assess nutrient utilization and evaluate mitochondrial complexes, shedding light on cellular energy dynamics. Tailored for a range of experimental models, including cell lines, patient-derived […]
Immunohistochemistry
We offer precise staining and analysis of tissue samples, enabling the detection and localization of specific proteins within their histological context. Our IHC platform provides critical insights into disease mechanisms, biomarker expression, and therapeutic target validation.
Cytokine Profiling
Our expertise include multiplex cytokine assays, ELISA, and intracellular cytokine staining, offering precise quantification and characterization of cytokines across a wide array of samples. We also provide flow cytometry-based analysis to evaluate cytokine production at the single-cell level. These methods are adaptable to various experimental models, including cell lines, patient-derived samples, and in vivo studies, […]
Multiplexed Immuno-Fluorescence
We enable simultaneous detection of multiple targets within a single tissue section, providing a detailed spatial understanding of cellular environments. Our mIF services are ideal for studying co-localization, cellular heterogeneity, and biomarker discovery.
Optimized CAR-T Cell Generation and Transduction
Advance your immunotherapy research with our comprehensive platform for T-cell activation and CAR-T cell generation. We specialize in optimizing T-cell transduction and generating CAR-T cells using classic CAR constructs like CD19-BBz and CD19-CD28. Our expertise ensures efficient and reliable production of CAR-T cells, tailored to meet your research needs.