In vitro modelisation – Memory B cells to plasma cell differentiation
Explore our in vitro model enabling the isolation of memory B cells from blood donors and their differentiation into plasma cells. This system supports the study of protein function through gene expression modulation or drug treatment and is extensively characterized at a molecular and epigenetic levels.
Genome Integrity Analysis: Replication and DNA Damage Detection
Our expertise include DNA combing, detection of cytosolic DNA and detection of DNA damage foci, enabling detailed study of DNA replication and genome stability. Allowing quantification of replication stress, fork resection, and DNA damage at both single-molecule and cellular levels, they help uncover mechanisms of cancer progression, inflammation, and potential therapeutic targets.
Hi-C
By detecting physical interactions between distant DNA segments, Hi-C offers insights into the spatial structure and folding of chromatin. Hi-C serves as a powerful tool for deciphering the principles governing chromatin organization, from the formation of topologically associating domains (TADs) to the spatial compartmentalization of regulatory elements and gene expression domains.
miRNA profiling
miRNA Profiling quantifies and characterizes microRNA expression to study their role in regulating gene expression. It helps identify biomarkers and potential therapeutic targets for cancer treatment.
ScienceLeadR
ScienceLeadR is an experts’ centric platform dedicated to connect the ecosystem of Life Sciences : Experts, Organizations, Academic Societies, BioTech, MedTech, Pharma Industry, … We provide a unique solution to qualify experts and organizations on all expertise at local or worldwide level. ScienceLeadR qualified more than 3.7 million experts. Based on a proprietary medical ontology, […]