Spatial Transcriptomics and Proteomics
By capturing the spatial distribution of RNA and proteins in situ, our transcriptomic and proteomic platforms provides a comprehensive view of gene and protein expression respectively, within their native tissue context. Based on multiple approaches (from single-cell spatial-Omics to imaging mass spectrometry) and our lymphoid neoplasm expertise, we explore spatially defined expression patterns, cell-cell interactions, […]
Transgenesis platform
Our transgenesis platform enables the generation of customized mouse models through precise genetic modifications, including gene overexpression, knock-in mutations, and conditional gene targeting. These models provide powerful tools to study gene function, disease mechanisms, and therapeutic strategies.
HemSys
HemSys is a Multidisciplinary Consultation Meeting (MCM) software package designed for use by healthcare professionals in the field of haematology. Each partner centre can use the tool securely to manage patients treated in its establishment. The HemSys tool consists of a Multidisciplinary Consultation Meeting (MCM) software package for haematology and an associated secure database.
French Connect
French Connect is an innovative liquid biopsy platform for sensitive ctDNA-based MRD monitoring in lymphoid malignancies. It enables early relapse prediction (PET-scan correlated), MRD follow-up in clinical trials, and ancillary studies. Developed by multi-disciplinary experts from 10 leading French academic centers, this platform offers ready-to-use panels for DLBCL, PMBL, and FL, along with an optimized […]
Advanced Flow Cytometry
Our platform combines multiparameter and spectral flow cytometry with FACS to analyze and isolate diverse cell populations, enabling high-resolution study of cellular heterogeneity and function in biomedical research.
Advanced Microscopy for Molecular Localization and Interaction
Our state-of-the-art microscopy techniques includes spectral confocal microscopy, microscopic nuclear localization, Fluorescence Resonance Energy Transfer (FRET) microscopy imaging, and cell imaging. Based-on high-resolution visualization of molecular events, we investigate cellular processes and structures, along with precise assessment of distances between Ig genes and oncogenes, unveiling new insights into gene regulation and oncogenic mechanisms.
ATAC-seq (bulk and single-cell)
ATAC-seq maps chromatin accessibility to reveal gene regulatory regions, both at bulk and single-cell resolution. Bulk ATAC-seq provides genome-wide snapshots of open chromatin across cell populations, while single-cell ATAC-seq uncovers cell-to-cell variability in chromatin states. This technique enables deeper understanding of gene regulation, cellular differentiation, and disease mechanisms, offering valuable insights for cancer research and […]
DNA methylation – ERRBS
Enhanced Reduced Representation Bisulfite Sequencing (ERRBS) maps DNA methylation at single-nucleotide resolution to study epigenetic regulation. It helps reveal cancer-associated epigenetic changes and identify potential biomarkers and therapeutic targets.
Epitranscriptomics
Our epitranscriptomics pipeline uses LC-MS/MS to detect and quantify RNA modifications, providing insights into RNA regulation. We use this innovative platform to unravel the intricacies of epitranscriptomic modifications during critical cellular processes such as B to plasma cell differentiation, lymphomagenesis, and myelomagenesis. It helps to shed light on the underlying molecular pathways driving disease progression […]
DNA-RNA immunoprecipitation sequencing (DRIP-seq)
DRIP-seq maps DNA-RNA hybrids (R-loops) across the genome to study their roles in gene regulation and genome stability. It helps reveal mechanisms of transcription, DNA repair, and chromatin organization, providing insights relevant to disease and potential therapeutic strategies.