Precision Genome Engineering: CRISPR Gene Editing, Barcoding, and Screening
Our platform enables precise genome editing in both cell lines and primary cells using CRISPR technology, supporting knockout, knock-in, gene tagging, and regulatory element modifications. Integrated with barcoding and high-throughput screening, it allows systematic functional genomics studies to dissect gene function, cellular pathways, and disease mechanisms. This combination of genome editing and scalable screening provides […]
Proteomics analysis
By employing advanced techniques for identification, quantification, and characterization, Proteomic Analysis offers a holistic understanding of protein expression patterns and functions. This powerful approach provides new insights into the molecular mechanisms underlying cellular processes, from signaling pathways to protein-protein interactions. By deciphering the proteome, we can uncover novel biomarkers, therapeutic targets, and pathways associated with […]
Mouse Model – DLBCL/FL
Gain access to our mouse models in FL/DLBCL, including vavP-BCL2 strain, KMT2D-flox CD19-cre strain and BTG1-KO strain (and more). These models enable to investigate novel drug targets and test for drug efficacy and toxicity
CAR-NK cells generation and characterization
Our expert teams specialize in the precise engineering of CAR-NK cells, tailoring them to recognize specific tumor antigens with high precision. Through functional characterization, we validate the potency and specificity of these engineered cells, ensuring their efficacy in targeting cancer cells while sparing healthy tissues.
2D-culture of primary cells from patients
Explore our 2D primary cell culture (with or without stroma) derived from patient samples (DLBCL, FL, MCL, MM…), enabling in-depth studies on B and T cells. Uncover new opportunities for drug and target discovery through precise gene expression modulation and comprehensive drug testing, encompassing small molecules, antibodies, and CAR-T cells.
DNA methylation – ERRBS
Enhanced Reduced Representation Bisulfite Sequencing (ERRBS) maps DNA methylation at single-nucleotide resolution to study epigenetic regulation. It helps reveal cancer-associated epigenetic changes and identify potential biomarkers and therapeutic targets.
Epitranscriptomics
Our epitranscriptomics pipeline uses LC-MS/MS to detect and quantify RNA modifications, providing insights into RNA regulation. We use this innovative platform to unravel the intricacies of epitranscriptomic modifications during critical cellular processes such as B to plasma cell differentiation, lymphomagenesis, and myelomagenesis. It helps to shed light on the underlying molecular pathways driving disease progression […]
BH3 profiling toolkit
Our BH3 mimetic toolkit measures early drug-induced changes in proapoptotic signaling, revealing shifts in antiapoptotic dependencies. It helps to identify novel drug targets and predictive biomarkers, and offers to assess cellular fate across diverse experimental settings.
DNA-RNA immunoprecipitation sequencing (DRIP-seq)
DRIP-seq maps DNA-RNA hybrids (R-loops) across the genome to study their roles in gene regulation and genome stability. It helps reveal mechanisms of transcription, DNA repair, and chromatin organization, providing insights relevant to disease and potential therapeutic strategies.
Okazaki fragments sequencing (OK-seq)
OK-seq enables researchers to map the genome-wide locations of proteins involved in DNA replication and replication fork directionality. By unraveling the spatial organization of replication machinery and Okazaki fragments, OK-seq offers insights into the coordination and regulation of DNA synthesis during genome replication. This approach provides information for understanding genome stability and cellular proliferation.