Optimized CAR-T Cell Generation and Transduction
Advance your immunotherapy research with our comprehensive platform for T-cell activation and CAR-T cell generation. We specialize in optimizing T-cell transduction and generating CAR-T cells using classic CAR constructs like CD19-BBz and CD19-CD28. Our expertise ensures efficient and reliable production of CAR-T cells, tailored to meet your research needs.
Labeled Nutrient-Transporter Ligand Production
Enhance your research with our specialized production of labeled nutrient-transporter ligands, developed in partnership with Metafora Biosystems. These labeled ligands enable precise detection of transporter expression, activity, and efficacy, offering new insights into nutrient transport mechanisms.
Comprehensive In Vitro and In Vivo Validation of CAR-T Cell Therapies
Evaluate and validate your CAR-T cell therapies with our comprehensive platform that combines in vitro co-culture assays and in vivo studies. Our in vitro assays rigorously assess the efficacy of CAR-T constructs against target cells in controlled environments. Following in vitro validation, we offer precise in vivo assays, including CAR-T cell injections and efficacy studies […]
Multicellulare Agregates of Lymphoma Cells (MALC)
Explore complex tumor biology with our Multicellular Aggregates of Lymphoma Cells (MALC) model. It mimics the 3D structure and microenvironment of lymphoma, providing a robust system for studying cell-cell interactions, tumor progression, and therapeutic responses. The MALC model enables more physiologically relevant insights compared to traditional 2D cultures, supporting the development of targeted lymphoma therapies.
3D Co-Culture of Lymphoma Cells with Gamma Delta T Cells
Explore our 3D co-culture system combining lymphoma cell lines and gamma delta T cells from healthy donors. This advanced model recreates the tumor microenvironment, allowing detailed study of immune-tumor interactions, gamma delta T cell cytotoxicity, and potential therapeutic mechanisms.
Proteomics analysis
By employing advanced techniques for identification, quantification, and characterization, Proteomic Analysis offers a holistic understanding of protein expression patterns and functions. This powerful approach provides new insights into the molecular mechanisms underlying cellular processes, from signaling pathways to protein-protein interactions. By deciphering the proteome, we can uncover novel biomarkers, therapeutic targets, and pathways associated with […]
RNA-seq (bulk and single-cell)
RNA sequencing (RNA-seq) is a powerful technique for analyzing gene expression at both bulk and single-cell levels. It reveals RNA abundance, splicing, and modifications, providing insights into cellular function, tissue organization, and disease mechanisms. Bulk RNA-seq profiles large cell populations, while single-cell RNA-seq uncovers cellular heterogeneity and rare cell types, aiding biomarker discovery, understanding drug […]
Single-Cell Analysis Technologies
Our cutting-edge platforms include scRNAseq, scATAseq, spatial transcriptomics, scBRC-seq, scTCRseq, and ECCITE-seq. By leveraging these advanced technologies, we investigate the heterogeneity within cell populations, uncover rare cell types, and decipher the molecular mechanisms underlying development, disease, and immune responses. Our integrated approach enables comprehensive profiling of individual cells, driving transformative discoveries in fields ranging from […]
Spatial Transcriptomics and Proteomics
By capturing the spatial distribution of RNA and proteins in situ, our transcriptomic and proteomic platforms provides a comprehensive view of gene and protein expression respectively, within their native tissue context. Based on multiple approaches (from single-cell spatial-Omics to imaging mass spectrometry) and our lymphoid neoplasm expertise, we explore spatially defined expression patterns, cell-cell interactions, […]
Transgenesis platform
Our transgenesis platform enables the generation of customized mouse models through precise genetic modifications, including gene overexpression, knock-in mutations, and conditional gene targeting. These models provide powerful tools to study gene function, disease mechanisms, and therapeutic strategies.