CAR-NK cells generation and characterization
Our expert teams specialize in the precise engineering of CAR-NK cells, tailoring them to recognize specific tumor antigens with high precision. Through functional characterization, we validate the potency and specificity of these engineered cells, ensuring their efficacy in targeting cancer cells while sparing healthy tissues.
2D-culture of primary cells from patients
Explore our 2D primary cell culture (with or without stroma) derived from patient samples (DLBCL, FL, MCL, MM…), enabling in-depth studies on B and T cells. Uncover new opportunities for drug and target discovery through precise gene expression modulation and comprehensive drug testing, encompassing small molecules, antibodies, and CAR-T cells.
DNA methylation – ERRBS
Enhanced Reduced Representation Bisulfite Sequencing (ERRBS) maps DNA methylation at single-nucleotide resolution to study epigenetic regulation. It helps reveal cancer-associated epigenetic changes and identify potential biomarkers and therapeutic targets.
Epitranscriptomics
Our epitranscriptomics pipeline uses LC-MS/MS to detect and quantify RNA modifications, providing insights into RNA regulation. We use this innovative platform to unravel the intricacies of epitranscriptomic modifications during critical cellular processes such as B to plasma cell differentiation, lymphomagenesis, and myelomagenesis. It helps to shed light on the underlying molecular pathways driving disease progression […]
BH3 profiling toolkit
Our BH3 mimetic toolkit measures early drug-induced changes in proapoptotic signaling, revealing shifts in antiapoptotic dependencies. It helps to identify novel drug targets and predictive biomarkers, and offers to assess cellular fate across diverse experimental settings.
3D bioprinting
3D Bioprinting allows the precise creation of complex tissue-like structures using cells and biomaterials. In oncology, it enables modeling of the tumor microenvironment to study cancer mechanisms and test new therapies.
Reverse Transcriptase Multiplex Ligation-dependant Probe Amplification (RT-MLPA)
RT-MLPA enables simultaneous detection and quantification of multiple RNA targets with high accuracy. In oncology, it is used to analyze gene expression signatures, identify biomarkers, and study disease mechanisms.
Proximity Ligation Assay (PLA)
Proximity Ligation Assay (PLA) enables precise detection and visualization of protein-protein interactions directly within cells. In oncology, it helps uncover signaling pathways, validate therapeutic targets, and reveal mechanisms driving cancer progression.
Immunoglobulin repertoire sequencing (Ig-Rep-Seq)
Immunoglobulin Repertoire Sequencing (Ig-Rep-Seq) deciphers the antibody diversity and immune responseat the single-cell level. This method can be used to study lymphoid malignancies, track immune responses, and guide cancer immunotherapy development.
Genome Integrity Analysis: Replication and DNA Damage Detection
Our expertise include DNA combing, detection of cytosolic DNA and detection of DNA damage foci, enabling detailed study of DNA replication and genome stability. Allowing quantification of replication stress, fork resection, and DNA damage at both single-molecule and cellular levels, they help uncover mechanisms of cancer progression, inflammation, and potential therapeutic targets.