Mouse Patient Derived Xenographt (Mouse-PDX) – Lymphoma
Explore our Mouse PDX models to investigate lymphoma biology, identify novel drug targets, or test for drug efficacy and toxicity. PDX models available for different lymphoma subtypes: AITL, CTCL,MCL, DLBCL, MZL, and more
Precision Gene Modulation with Antisense Oligonucleotides (ASOs)
Our advanced Antisense Oligonucleotides (ASOs) design technologys offer a versatile approach for precisely manipulating gene expression, including the potent capability of exon skipping to modulate protein production, such as Ig genes or BCR, by targeting donor splice sites. This method is compatible with both cell lines and primary cells, offering flexibility and applicability across various […]
Precision Genome Engineering: CRISPR Gene Editing, Barcoding, and Screening
Our platform enables precise genome editing in both cell lines and primary cells using CRISPR technology, supporting knockout, knock-in, gene tagging, and regulatory element modifications. Integrated with barcoding and high-throughput screening, it allows systematic functional genomics studies to dissect gene function, cellular pathways, and disease mechanisms. This combination of genome editing and scalable screening provides […]
Proteomics analysis
By employing advanced techniques for identification, quantification, and characterization, Proteomic Analysis offers a holistic understanding of protein expression patterns and functions. This powerful approach provides new insights into the molecular mechanisms underlying cellular processes, from signaling pathways to protein-protein interactions. By deciphering the proteome, we can uncover novel biomarkers, therapeutic targets, and pathways associated with […]
RNA-seq (bulk and single-cell)
RNA sequencing (RNA-seq) is a powerful technique for analyzing gene expression at both bulk and single-cell levels. It reveals RNA abundance, splicing, and modifications, providing insights into cellular function, tissue organization, and disease mechanisms. Bulk RNA-seq profiles large cell populations, while single-cell RNA-seq uncovers cellular heterogeneity and rare cell types, aiding biomarker discovery, understanding drug […]
Single-Cell Analysis Technologies
Our cutting-edge platforms include scRNAseq, scATAseq, spatial transcriptomics, scBRC-seq, scTCRseq, and ECCITE-seq. By leveraging these advanced technologies, we investigate the heterogeneity within cell populations, uncover rare cell types, and decipher the molecular mechanisms underlying development, disease, and immune responses. Our integrated approach enables comprehensive profiling of individual cells, driving transformative discoveries in fields ranging from […]
CRISPR Screening Platform
This academic platform proposes to perform CRISPR-based screens, enabling the comprehensive interrogation of the functional consequences of a genomic modification at the whole-genome scale, revealing how genomic alterations in coding or regulatory regions lead to phenotypic changes. The coordinator of the platform is Sandrine Roulland.
2D-culture of primary cells from patients
Explore our 2D primary cell culture (with or without stroma) derived from patient samples (DLBCL, FL, MCL, MM…), enabling in-depth studies on B and T cells. Uncover new opportunities for drug and target discovery through precise gene expression modulation and comprehensive drug testing, encompassing small molecules, antibodies, and CAR-T cells.
DNA methylation – ERRBS
Enhanced Reduced Representation Bisulfite Sequencing (ERRBS) maps DNA methylation at single-nucleotide resolution to study epigenetic regulation. It helps reveal cancer-associated epigenetic changes and identify potential biomarkers and therapeutic targets.
Epitranscriptomics
Our epitranscriptomics pipeline uses LC-MS/MS to detect and quantify RNA modifications, providing insights into RNA regulation. We use this innovative platform to unravel the intricacies of epitranscriptomic modifications during critical cellular processes such as B to plasma cell differentiation, lymphomagenesis, and myelomagenesis. It helps to shed light on the underlying molecular pathways driving disease progression […]