Lymphoma Data Hub (LDH)
The LDH is a collaborative research platform in digital health, specialized in data management and technological support for biomedical research. Our services include secure cloud hosting for health data, end-to-end data management from raw data deposit to ready-to-use datasets, and the deployment of advanced tools to enable research projects in artificial intelligence and bioinformatics.
Nutrient Metabolism analysis and characterization
Our expertise include profiling intracellular metabolites by LC-MS, tracing metabolites into fatty acids, and performing lipidomic analysis for a comprehensive understanding of lipid metabolism. We also offer extracellular flux analysis to assess nutrient utilization and evaluate mitochondrial complexes, shedding light on cellular energy dynamics. Tailored for a range of experimental models, including cell lines, patient-derived […]
Cytokine Profiling
Our expertise include multiplex cytokine assays, ELISA, and intracellular cytokine staining, offering precise quantification and characterization of cytokines across a wide array of samples. We also provide flow cytometry-based analysis to evaluate cytokine production at the single-cell level. These methods are adaptable to various experimental models, including cell lines, patient-derived samples, and in vivo studies, […]
Optimized CAR-T Cell Generation and Transduction
Advance your immunotherapy research with our comprehensive platform for T-cell activation and CAR-T cell generation. We specialize in optimizing T-cell transduction and generating CAR-T cells using classic CAR constructs like CD19-BBz and CD19-CD28. Our expertise ensures efficient and reliable production of CAR-T cells, tailored to meet your research needs.
Labeled Nutrient-Transporter Ligand Production
Enhance your research with our specialized production of labeled nutrient-transporter ligands, developed in partnership with Metafora Biosystems. These labeled ligands enable precise detection of transporter expression, activity, and efficacy, offering new insights into nutrient transport mechanisms.
Comprehensive In Vitro and In Vivo Validation of CAR-T Cell Therapies
Evaluate and validate your CAR-T cell therapies with our comprehensive platform that combines in vitro co-culture assays and in vivo studies. Our in vitro assays rigorously assess the efficacy of CAR-T constructs against target cells in controlled environments. Following in vitro validation, we offer precise in vivo assays, including CAR-T cell injections and efficacy studies […]
Advanced Microscopy for Molecular Localization and Interaction
Our state-of-the-art microscopy techniques includes spectral confocal microscopy, microscopic nuclear localization, Fluorescence Resonance Energy Transfer (FRET) microscopy imaging, and cell imaging. Based-on high-resolution visualization of molecular events, we investigate cellular processes and structures, along with precise assessment of distances between Ig genes and oncogenes, unveiling new insights into gene regulation and oncogenic mechanisms.
French Connect
French Connect is an innovative liquid biopsy platform for sensitive ctDNA-based MRD monitoring in lymphoid malignancies. It enables early relapse prediction (PET-scan correlated), MRD follow-up in clinical trials, and ancillary studies. Developed by multi-disciplinary experts from 10 leading French academic centers, this platform offers ready-to-use panels for DLBCL, PMBL, and FL, along with an optimized […]
ATAC-seq (bulk and single-cell)
ATAC-seq maps chromatin accessibility to reveal gene regulatory regions, both at bulk and single-cell resolution. Bulk ATAC-seq provides genome-wide snapshots of open chromatin across cell populations, while single-cell ATAC-seq uncovers cell-to-cell variability in chromatin states. This technique enables deeper understanding of gene regulation, cellular differentiation, and disease mechanisms, offering valuable insights for cancer research and […]
B-cell lymphoma cell lines
Explore our diverse range of B-cell lymphoma cell lines (PMBL, MCL, FL, DLBCL, BL), including parental and CRISPR- or shRNA-engineered models, and extensively characterized at molecular and phenotypic levels. Our collection also includes EBV-transformed cell lines and drug-resistant lines, supporting research on lymphoma biology, therapeutic targets, and resistance mechanisms.