CITE-seq
CITE-seq combines single-cell RNA sequencing with protein detection to analyze cell populations in detail. Our platform facilitates comprehensive characterization of cell types, states, and interactions, enabling to profile immune cell responses,to identify rare cell populations, or to unravel disease mechanisms
ECCITE-seq
ECCITE-seq combines CRISPR perturbations, RNA sequencing, and protein detection at the single-cell level, enabling integrated analysis of transcriptome, genome, and proteome. This technique provides deep insights into cellular states and regulatory networks, serving as a powerful tool for CRISPR screens, functional genomics, and precision medicine research.
CRISPR Screening Platform
This academic platform proposes to perform CRISPR-based screens, enabling the comprehensive interrogation of the functional consequences of a genomic modification at the whole-genome scale, revealing how genomic alterations in coding or regulatory regions lead to phenotypic changes. The coordinator of the platform is Sandrine Roulland.
2D-culture of primary cells from patients
Explore our 2D primary cell culture (with or without stroma) derived from patient samples (DLBCL, FL, MCL, MM…), enabling in-depth studies on B and T cells. Uncover new opportunities for drug and target discovery through precise gene expression modulation and comprehensive drug testing, encompassing small molecules, antibodies, and CAR-T cells.
Hi-C
By detecting physical interactions between distant DNA segments, Hi-C offers insights into the spatial structure and folding of chromatin. Hi-C serves as a powerful tool for deciphering the principles governing chromatin organization, from the formation of topologically associating domains (TADs) to the spatial compartmentalization of regulatory elements and gene expression domains.
miRNA profiling
miRNA Profiling quantifies and characterizes microRNA expression to study their role in regulating gene expression. It helps identify biomarkers and potential therapeutic targets for cancer treatment.
Multiplex Immunohistochemistry
Multiplex Immunohistochemistry (IHC) enables the simultaneous detection of multiple proteins within a single tissue sample, revealing cellular architecture and interactions. In oncology, it provides critical insights into tumor composition, microenvironment, and potential therapeutic targets.
Mouse Model
Explore our available mouse models (drug resistant, immuno-competent, or immuno-deficient strains) to investigate lymphoma biology and identify novel drug targets.
3D bioprinting
3D Bioprinting allows the precise creation of complex tissue-like structures using cells and biomaterials. In oncology, it enables modeling of the tumor microenvironment to study cancer mechanisms and test new therapies.