Ex vivo Expansion of Patient-Derived iNKT Cells
Enhance your immunotherapy research with our specialized platform for the ex vivo expansion of invariant natural killer T (iNKT) cells from patient samples. Our optimized protocols ensure robust expansion of iNKT cells, providing a reliable source of these critical immune effectors for research and therapeutic applications.
Ex vivo Expansion of Normal and Pathological CD34+ Cells
Explore our advanced in vitro model for the expansion of normal and pathological CD34+ cells. Optimized protocols enable efficient and scalable production of hematopoietic stem and progenitor cells, providing a robust system to study blood disorders, stem cell biology, and regenerative therapies in both basic and preclinical research.
Feline Model for Low-Grade Intestinal T-Cell Lymphoma
Explore our unique spontaneous animal model for low-grade intestinal T-cell lymphoma, a natural feline model that closely mirrors human indolent T-cell lymphoproliferative disorders of the gastrointestinal tract. This model provides novel insights into disease progression, immune response, and therapeutic interventions, offering a rare opportunity to study this condition in a natural setting.
Single-Cell Analysis Technologies
Our cutting-edge platforms include scRNAseq, scATAseq, spatial transcriptomics, scBRC-seq, scTCRseq, and ECCITE-seq. By leveraging these advanced technologies, we investigate the heterogeneity within cell populations, uncover rare cell types, and decipher the molecular mechanisms underlying development, disease, and immune responses. Our integrated approach enables comprehensive profiling of individual cells, driving transformative discoveries in fields ranging from […]
Advanced Flow Cytometry
Our platform combines multiparameter and spectral flow cytometry with FACS to analyze and isolate diverse cell populations, enabling high-resolution study of cellular heterogeneity and function in biomedical research.
Spatial Transcriptomics and Proteomics
By capturing the spatial distribution of RNA and proteins in situ, our transcriptomic and proteomic platforms provides a comprehensive view of gene and protein expression respectively, within their native tissue context. Based on multiple approaches (from single-cell spatial-Omics to imaging mass spectrometry) and our lymphoid neoplasm expertise, we explore spatially defined expression patterns, cell-cell interactions, […]
Advanced Microscopy for Molecular Localization and Interaction
Our state-of-the-art microscopy techniques includes spectral confocal microscopy, microscopic nuclear localization, Fluorescence Resonance Energy Transfer (FRET) microscopy imaging, and cell imaging. Based-on high-resolution visualization of molecular events, we investigate cellular processes and structures, along with precise assessment of distances between Ig genes and oncogenes, unveiling new insights into gene regulation and oncogenic mechanisms.
Transgenesis platform
Our transgenesis platform enables the generation of customized mouse models through precise genetic modifications, including gene overexpression, knock-in mutations, and conditional gene targeting. These models provide powerful tools to study gene function, disease mechanisms, and therapeutic strategies.
ATAC-seq (bulk and single-cell)
ATAC-seq maps chromatin accessibility to reveal gene regulatory regions, both at bulk and single-cell resolution. Bulk ATAC-seq provides genome-wide snapshots of open chromatin across cell populations, while single-cell ATAC-seq uncovers cell-to-cell variability in chromatin states. This technique enables deeper understanding of gene regulation, cellular differentiation, and disease mechanisms, offering valuable insights for cancer research and […]
HemSys
HemSys is a Multidisciplinary Consultation Meeting (MCM) software package designed for use by healthcare professionals in the field of haematology. Each partner centre can use the tool securely to manage patients treated in its establishment. The HemSys tool consists of a Multidisciplinary Consultation Meeting (MCM) software package for haematology and an associated secure database.