HemSys
HemSys is a Multidisciplinary Consultation Meeting (MCM) software package designed for use by healthcare professionals in the field of haematology. Each partner centre can use the tool securely to manage patients treated in its establishment. The HemSys tool consists of a Multidisciplinary Consultation Meeting (MCM) software package for haematology and an associated secure database.
B-cell lymphoma cell lines
Explore our diverse range of B-cell lymphoma cell lines (PMBL, MCL, FL, DLBCL, BL), including parental and CRISPR- or shRNA-engineered models, and extensively characterized at molecular and phenotypic levels. Our collection also includes EBV-transformed cell lines and drug-resistant lines, supporting research on lymphoma biology, therapeutic targets, and resistance mechanisms.
French Connect
French Connect is an innovative liquid biopsy platform for sensitive ctDNA-based MRD monitoring in lymphoid malignancies. It enables early relapse prediction (PET-scan correlated), MRD follow-up in clinical trials, and ancillary studies. Developed by multi-disciplinary experts from 10 leading French academic centers, this platform offers ready-to-use panels for DLBCL, PMBL, and FL, along with an optimized […]
Genetically engineered mouse models
Gain access to our expertise to engineer unique « à la carte » transgenic mouse models.
Mouse Model – B-cell Lymphoma
Gain access to our engineered mouse models, including CD19-Cre transgenic strain (allowing conditional engineering in B cells), BCL2tracer strain (mimicking sporadic t(14;18) translocation), AID-Cre-ERT2 KI/KO strain (used to monitor memory B cell population), RosaYFP Reporter strain, MLL4 f/F strain, Cas9-GFP Cre strain, and BCL2/KDMT2D knock-out strain (either as a syngenic chimera model or xenograft), and […]
ECCITE-seq
ECCITE-seq combines CRISPR perturbations, RNA sequencing, and protein detection at the single-cell level, enabling integrated analysis of transcriptome, genome, and proteome. This technique provides deep insights into cellular states and regulatory networks, serving as a powerful tool for CRISPR screens, functional genomics, and precision medicine research.
CRISPR Screening Platform
This academic platform proposes to perform CRISPR-based screens, enabling the comprehensive interrogation of the functional consequences of a genomic modification at the whole-genome scale, revealing how genomic alterations in coding or regulatory regions lead to phenotypic changes. The coordinator of the platform is Sandrine Roulland.
Patient Derived Organoids – Follicular lymphoma
Discover our organoid model derived from FL patient primary cells (tumor and microenvironment), cultured in vitro on a peptide-based gel matrix. This system enables drug and target discovery through gene expression modulation and extensive screening of small molecules, antibodies, and CAR-T cells. Each sample is linked to clinical data and integrated into a predictive model […]
Mouse Model – DLBCL/FL
Gain access to our mouse models in FL/DLBCL, including vavP-BCL2 strain, KMT2D-flox CD19-cre strain and BTG1-KO strain (and more). These models enable to investigate novel drug targets and test for drug efficacy and toxicity
Mouse Model – Natural killer/T-Cell lymphoma
Gain access to this mouse model (p53-KO x JARID-KO-flox x CD4-cre) for investigating NK/T-cell lymphoma biology, identifying novel drug targets and testing for drug efficacy and toxicity