DNA-RNA immunoprecipitation sequencing (DRIP-seq)
DRIP-seq maps DNA-RNA hybrids (R-loops) across the genome to study their roles in gene regulation and genome stability. It helps reveal mechanisms of transcription, DNA repair, and chromatin organization, providing insights relevant to disease and potential therapeutic strategies.
Okazaki fragments sequencing (OK-seq)
OK-seq enables researchers to map the genome-wide locations of proteins involved in DNA replication and replication fork directionality. By unraveling the spatial organization of replication machinery and Okazaki fragments, OK-seq offers insights into the coordination and regulation of DNA synthesis during genome replication. This approach provides information for understanding genome stability and cellular proliferation.
In vitro modelisation – Naïve B cells to plasma cell differentiation
We offer an in vitro model of B-cell terminal differentiation, based on the isolation and activation of donor-derived B-cells. This system allows functional studies of specific proteins through gene expression modulation with antisense technology and is fully characterized by immunoglobulin isoform analysis.
Long term in vitro culture of chronic lymphocytic leukemia primary cells
We provide a primary cell culture platform derived from patient samples, enabling precise gene expression modulation and comprehensive drug testing. This system supports target discovery and the evaluation of small molecules, antibodies, and CAR-T cell therapies.
Mouse Model for lymphoid neoplasms – DLBCL
Explore our mouse models designed respectively for the study of DLBCL, Burkitt Lymphoma, Amyloid light-chain amylosis, Multiple Myeloma, or Fanconi Syndrom, Light and heavy chain deposition disease. These models enable the identification of novel therapeutic targets as well as the evaluation of drug efficacy and toxicity.
Mouse Model – Humanized IgG/E/A/M
Gain access to humanized IgG/E/A/M transgenic mouse model.
Mouse Model – Plasma cell-specific inducible Cre
Gain access to Plasma cell-specific inducible Cre transgenic mouse model
Transgenic mouse model development
Gain access to our expertise to engineer unique « à la carte » transgenic mouse models.
Immunoglobulin repertoire sequencing (Ig-Rep-Seq)
Immunoglobulin Repertoire Sequencing (Ig-Rep-Seq) deciphers the antibody diversity and immune responseat the single-cell level. This method can be used to study lymphoid malignancies, track immune responses, and guide cancer immunotherapy development.
In vitro modelisation – Memory B cells to plasma cell differentiation
Explore our in vitro model enabling the isolation of memory B cells from blood donors and their differentiation into plasma cells. This system supports the study of protein function through gene expression modulation or drug treatment and is extensively characterized at a molecular and epigenetic levels.