Mouse Patient Derived Xenographt (Mouse-PDX) – Lymphoma
Explore our Mouse PDX models to investigate lymphoma biology, identify novel drug targets, or test for drug efficacy and toxicity. PDX models available for different lymphoma subtypes: AITL, CTCL,MCL, DLBCL, MZL, and more
Multiple Myeloma cell lines
Explore our panel of human myeloma cell lines, including parental and CRISPR- or shRNA-engineered models, extensively characterized at molecular and phenotypic levels. Our collection also includes drug-resistant lines, supporting research on multiple myeloma biology, therapeutic targets, and resistance mechanisms
Precision Gene Modulation with Antisense Oligonucleotides (ASOs)
Our advanced Antisense Oligonucleotides (ASOs) design technologys offer a versatile approach for precisely manipulating gene expression, including the potent capability of exon skipping to modulate protein production, such as Ig genes or BCR, by targeting donor splice sites. This method is compatible with both cell lines and primary cells, offering flexibility and applicability across various […]
Precision Genome Engineering: CRISPR Gene Editing, Barcoding, and Screening
Our platform enables precise genome editing in both cell lines and primary cells using CRISPR technology, supporting knockout, knock-in, gene tagging, and regulatory element modifications. Integrated with barcoding and high-throughput screening, it allows systematic functional genomics studies to dissect gene function, cellular pathways, and disease mechanisms. This combination of genome editing and scalable screening provides […]
RNA-seq (bulk and single-cell)
RNA sequencing (RNA-seq) is a powerful technique for analyzing gene expression at both bulk and single-cell levels. It reveals RNA abundance, splicing, and modifications, providing insights into cellular function, tissue organization, and disease mechanisms. Bulk RNA-seq profiles large cell populations, while single-cell RNA-seq uncovers cellular heterogeneity and rare cell types, aiding biomarker discovery, understanding drug […]
Single-Cell Analysis Technologies
Our cutting-edge platforms include scRNAseq, scATAseq, spatial transcriptomics, scBRC-seq, scTCRseq, and ECCITE-seq. By leveraging these advanced technologies, we investigate the heterogeneity within cell populations, uncover rare cell types, and decipher the molecular mechanisms underlying development, disease, and immune responses. Our integrated approach enables comprehensive profiling of individual cells, driving transformative discoveries in fields ranging from […]
Spatial Transcriptomics and Proteomics
By capturing the spatial distribution of RNA and proteins in situ, our transcriptomic and proteomic platforms provides a comprehensive view of gene and protein expression respectively, within their native tissue context. Based on multiple approaches (from single-cell spatial-Omics to imaging mass spectrometry) and our lymphoid neoplasm expertise, we explore spatially defined expression patterns, cell-cell interactions, […]
Advanced Flow Cytometry
Our platform combines multiparameter and spectral flow cytometry with FACS to analyze and isolate diverse cell populations, enabling high-resolution study of cellular heterogeneity and function in biomedical research.
Transgenesis platform
Our transgenesis platform enables the generation of customized mouse models through precise genetic modifications, including gene overexpression, knock-in mutations, and conditional gene targeting. These models provide powerful tools to study gene function, disease mechanisms, and therapeutic strategies.
Advanced Microscopy for Molecular Localization and Interaction
Our state-of-the-art microscopy techniques includes spectral confocal microscopy, microscopic nuclear localization, Fluorescence Resonance Energy Transfer (FRET) microscopy imaging, and cell imaging. Based-on high-resolution visualization of molecular events, we investigate cellular processes and structures, along with precise assessment of distances between Ig genes and oncogenes, unveiling new insights into gene regulation and oncogenic mechanisms.