Genetically engineered mouse models
Gain access to our expertise to engineer unique « à la carte » transgenic mouse models.
Mouse Model – B-cell Lymphoma
Gain access to our engineered mouse models, including CD19-Cre transgenic strain (allowing conditional engineering in B cells), BCL2tracer strain (mimicking sporadic t(14;18) translocation), AID-Cre-ERT2 KI/KO strain (used to monitor memory B cell population), RosaYFP Reporter strain, MLL4 f/F strain, Cas9-GFP Cre strain, and BCL2/KDMT2D knock-out strain (either as a syngenic chimera model or xenograft), and […]
ECCITE-seq
ECCITE-seq combines CRISPR perturbations, RNA sequencing, and protein detection at the single-cell level, enabling integrated analysis of transcriptome, genome, and proteome. This technique provides deep insights into cellular states and regulatory networks, serving as a powerful tool for CRISPR screens, functional genomics, and precision medicine research.
CRISPR Screening Platform
This academic platform proposes to perform CRISPR-based screens, enabling the comprehensive interrogation of the functional consequences of a genomic modification at the whole-genome scale, revealing how genomic alterations in coding or regulatory regions lead to phenotypic changes. The coordinator of the platform is Sandrine Roulland.
2D-culture of primary cells from patients
Explore our 2D primary cell culture (with or without stroma) derived from patient samples (DLBCL, FL, MCL, MM…), enabling in-depth studies on B and T cells. Uncover new opportunities for drug and target discovery through precise gene expression modulation and comprehensive drug testing, encompassing small molecules, antibodies, and CAR-T cells.
Mouse Model
Explore our available mouse models (drug resistant, immuno-competent, or immuno-deficient strains) to investigate lymphoma biology and identify novel drug targets.
3D bioprinting
3D Bioprinting allows the precise creation of complex tissue-like structures using cells and biomaterials. In oncology, it enables modeling of the tumor microenvironment to study cancer mechanisms and test new therapies.
3D bioprinting facility
Reverse Transcriptase Multiplex Ligation-dependant Probe Amplification (RT-MLPA)
RT-MLPA enables simultaneous detection and quantification of multiple RNA targets with high accuracy. In oncology, it is used to analyze gene expression signatures, identify biomarkers, and study disease mechanisms.
Cell-free DNA (cfDNA) analysis
Cell-free DNA (cfDNA) analysis detects genetic mutations from DNA fragments circulating in blood or urine, offering a non-invasive alternative to tissue biopsies. In oncology, it is widely used to identify tumor mutations, monitor treatment response, and track disease progression.