Precision Gene Modulation with Antisense Oligonucleotides (ASOs)
Our advanced Antisense Oligonucleotides (ASOs) design technologys offer a versatile approach for precisely manipulating gene expression, including the potent capability of exon skipping to modulate protein production, such as Ig genes or BCR, by targeting donor splice sites. This method is compatible with both cell lines and primary cells, offering flexibility and applicability across various […]
Precision Genome Engineering: CRISPR Gene Editing, Barcoding, and Screening
Our platform enables precise genome editing in both cell lines and primary cells using CRISPR technology, supporting knockout, knock-in, gene tagging, and regulatory element modifications. Integrated with barcoding and high-throughput screening, it allows systematic functional genomics studies to dissect gene function, cellular pathways, and disease mechanisms. This combination of genome editing and scalable screening provides […]
Proteomics analysis
By employing advanced techniques for identification, quantification, and characterization, Proteomic Analysis offers a holistic understanding of protein expression patterns and functions. This powerful approach provides new insights into the molecular mechanisms underlying cellular processes, from signaling pathways to protein-protein interactions. By deciphering the proteome, we can uncover novel biomarkers, therapeutic targets, and pathways associated with […]
RNA-seq (bulk and single-cell)
RNA sequencing (RNA-seq) is a powerful technique for analyzing gene expression at both bulk and single-cell levels. It reveals RNA abundance, splicing, and modifications, providing insights into cellular function, tissue organization, and disease mechanisms. Bulk RNA-seq profiles large cell populations, while single-cell RNA-seq uncovers cellular heterogeneity and rare cell types, aiding biomarker discovery, understanding drug […]
Single-Cell Analysis Technologies
Our cutting-edge platforms include scRNAseq, scATAseq, spatial transcriptomics, scBRC-seq, scTCRseq, and ECCITE-seq. By leveraging these advanced technologies, we investigate the heterogeneity within cell populations, uncover rare cell types, and decipher the molecular mechanisms underlying development, disease, and immune responses. Our integrated approach enables comprehensive profiling of individual cells, driving transformative discoveries in fields ranging from […]
Spatial Transcriptomics and Proteomics
By capturing the spatial distribution of RNA and proteins in situ, our transcriptomic and proteomic platforms provides a comprehensive view of gene and protein expression respectively, within their native tissue context. Based on multiple approaches (from single-cell spatial-Omics to imaging mass spectrometry) and our lymphoid neoplasm expertise, we explore spatially defined expression patterns, cell-cell interactions, […]
Mouse Model – Peripheral T-cell lymphoma (PTCL)
Gain access to this mouse model to investigate PTCL biology, identifying novel drug targets and testing for drug efficacy and toxicity
CAR-NK cells generation and characterization
Our expert teams specialize in the precise engineering of CAR-NK cells, tailoring them to recognize specific tumor antigens with high precision. Through functional characterization, we validate the potency and specificity of these engineered cells, ensuring their efficacy in targeting cancer cells while sparing healthy tissues.
T-cell lymphoma cell lines
Explore our available T-cell lymphoma cell lines (>21). Conduct in-depth experiments to unravel the biology of T-cell lymphoma and identify novel drug targets.
DNA methylation – ERRBS
Enhanced Reduced Representation Bisulfite Sequencing (ERRBS) maps DNA methylation at single-nucleotide resolution to study epigenetic regulation. It helps reveal cancer-associated epigenetic changes and identify potential biomarkers and therapeutic targets.