Mouse Model – DLBCL/FL
Gain access to our mouse models in FL/DLBCL, including vavP-BCL2 strain, KMT2D-flox CD19-cre strain and BTG1-KO strain (and more). These models enable to investigate novel drug targets and test for drug efficacy and toxicity
Mouse Model
Explore our available mouse models (drug resistant, immuno-competent, or immuno-deficient strains) to investigate lymphoma biology and identify novel drug targets.
Mouse Model – Eµ-myc
We provide Eµ-myc mouse model for non-Hodgkin B cell lymphoma study, characterized for response to chemotherapies and to metabolic inhibitors, metabolomic (carbon tracing), and transcriptomic.
In vitro modelisation – Naïve B cells to plasma cell differentiation
We offer an in vitro model of B-cell terminal differentiation, based on the isolation and activation of donor-derived B-cells. This system allows functional studies of specific proteins through gene expression modulation with antisense technology and is fully characterized by immunoglobulin isoform analysis.
Long term in vitro culture of chronic lymphocytic leukemia primary cells
We provide a primary cell culture platform derived from patient samples, enabling precise gene expression modulation and comprehensive drug testing. This system supports target discovery and the evaluation of small molecules, antibodies, and CAR-T cell therapies.
Mouse Model for lymphoid neoplasms – DLBCL
Explore our mouse models designed respectively for the study of DLBCL, Burkitt Lymphoma, Amyloid light-chain amylosis, Multiple Myeloma, or Fanconi Syndrom, Light and heavy chain deposition disease. These models enable the identification of novel therapeutic targets as well as the evaluation of drug efficacy and toxicity.
Mouse Model – Humanized IgG/E/A/M
Gain access to humanized IgG/E/A/M transgenic mouse model.
Mouse Model – Plasma cell-specific inducible Cre
Gain access to Plasma cell-specific inducible Cre transgenic mouse model
Transgenic mouse model development
Gain access to our expertise to engineer unique « à la carte » transgenic mouse models.
In vitro modelisation – Memory B cells to plasma cell differentiation
Explore our in vitro model enabling the isolation of memory B cells from blood donors and their differentiation into plasma cells. This system supports the study of protein function through gene expression modulation or drug treatment and is extensively characterized at a molecular and epigenetic levels.